The studies of Czajka et al. [127] and Scheele et al. [144] observed that patients with prediabetes (with no important hyperglycemia) presented an increase in the expression levels of mitophagy genes: PINK1 and Parkin, NIX and patients with T2D had reduced expression of mitophagy-related genes. This evidence concerns the gene PRKN and type 2 diabetes mellitus.