Experimental studies with human proximal tubular epithelial cells (PTECs—HKC-8) exposed to AGEs and with Zucker diabetic fatty rats demonstrated that liraglutide (a GLP-1R agonist) activates autophagy and reduces oxidative stress via AMPK/mTOR pathway and improve the prognosis of DKD [156,157,158]. Here, MTOR is linked to diabetic kidney disease.