Studies showed that if resveratrol activates the expression of BNIP3, Sirt, and Beclin 1 [146], quercetin reduces the aging of renal tubular epithelial cells via the SIRT1/PINK1 mitophagy pathway [122] and coenzyme Q10 (CoQ10) activates mitophagy by restoring antioxidant response element—Nrf2 in diabetic nephropathy [127,152]. The gene discussed is BNIP3; the disease is diabetic kidney disease.