We also provided the evidence that CUR pre-treatment exhibits a significant induction of mitochondrial apoptotic pathway (cleaved caspases 9, 3 and cleaved PARP) in CDDP-resistant ovarian cancer SKOV-3/CDDP with therapeutic potential apparently due to resensitize to CDDP toxicity through downregulation of thioredoxin reductase (TRXR1) and mTOR/STAT3 signaling pathway. This evidence concerns the gene STAT3 and ovarian carcinoma.