HMOX1 and ovarian adenocarcinoma: Treatment with CUR alone significantly inhibited the growth of human ovarian adenocarcinoma SKOV-3/CDDP CDDP-resistant subline cells by inhibition the gene expression of the antioxidant enzymes (SOD1, SOD2, GPX1, CAT, and HO1), transcription factor NFE2L2 and signaling pathway (PIK3CA/AKT1/MTOR) [22].