LGALS9 and hepatocellular carcinoma: On the other hand, high expression of Gal-4 and -9 has been reported to be associated with favorable overall survival in HCC patients (Gal-4: HR = 0.53, 95% CI = 0.36–0.79, p = 0.002; Gal-9: HR = 0.56, 95% CI = 0.44–0.71, p < 0.001) [166].