High expression of Gal-1 and -3 in tissues of HCC patients has been shown to be associated with poor overall survival (Gal-1: HR = 1.94, 95% CI = 1.61–2.34, p < 0.001; Gal-3: HR = 3.29, 95% CI = 1.62–6.68, p < 0.001). This evidence concerns the gene LGALS3 and hepatocellular carcinoma.