Methionine restriction was able to markedly inhibit the growth of PC-3 and DU145 (androgen-insensitive) cells in vitro; meanwhile, LNCaP (androgen-sensitive) cells exhibited a weaker dependence on methionine [47], implying an even more increased demand for methionine in advanced, AR-null PCa. The gene discussed is AR; the disease is posterior cortical atrophy.