It is noteworthy that after the treatment of PCa cell lines, such as LNCaP, PC3 and 22Rv1, with GCN2iB (a specific competitive inhibitor of GCN2), the growth of these cells was impeded, and a series of genes engaged in AAM were downregulated at both the transcription and translation levels, such as ASNS (induced by ATF4) and a range of SLC gene family members, including SLC7A11 (encoding xCT), SLC7A5 (encoding LAT1) and SLC3A2 (encoding 4F2) [161]. Here, ATF4 is linked to posterior cortical atrophy.