However, when we used the obtained 10 genes (CBS, CD34, EID3, ENO1, IGFBP1, INPP4B, PON1, SERPINE1, WEE1, and YBX1) as marker genes for HCC discrimination, the results showed that although the combined regression analysis of these senescence-related genes could predict survival time with high accuracy, the majority of genes alone were not effective in discriminating cancer samples (Supplementary Figure S1). The gene discussed is PON1; the disease is cancer.