The multinomial logistic regression analysis adjusted for the variables [sex, age, BMI, diabetes, arterial hypertension, Mediterranean diet compliance, physical exercise, smoking, drugs administration (including anticoagulant/antiaggregant, statins, and GLP1-Receptor Agonist- GLP1-RA), and alcohol intake] revealed the FLAME index as the only variable significantly associated with the 5-year occurrence of the first ACE for MASLD patients (Supplementary Table S2). The gene discussed is GLP1R; the disease is Hypertension.