Our IPA analysis highlights a potential linkage between the early activation of inflammatory and thrombotic pathways, such as TNFR1, TWEAK, and GP6 signaling, and the three candidate circulating miRNAs, miR-140-5p, miR-210-3p, and miR-7-5p, identified within the first 6 h of large vessel occlusion (LVO) stroke. Here, TNFSF12 is linked to stroke disorder.