In response to transient focal ischemia with reperfusion, miR-210-3p is upregulated in the cortex.When a miR-210-3p mimic is administered in vivo, it changes the expression of key signaling molecules like PTEN, PDK1, p70S6K, and RPS6.This manipulation also results in a decrease in p70S6K activity following an ischemic stroke.miR-210-3p influences p70S6K activity in response to NMDA-mediated excitotoxicity, and this effect can be reversed by inhibiting miR-210-3p.Pre-treatment with 5 pmol miR-210-3p mimic resulted in a significant decrease in hemispheric swelling and infarct volume. The gene discussed is PDK1; the disease is ischemic stroke.