miR210 injection reduced TET2 in the brain, but miR210 inhibition or KO preserved TET2 irrespective of brain injury.TET2 reduction reversed miR210 inhibition’s protective effects on stroke-induced brain damage and neurobehavioral deficits.Lowering TET2 weakened miR210’s anti-inflammatory impact on microglial activation and IL-6 release after stroke.Boosting TET2 in microglia counteracted miR210-induced cytokine increase. Here, IL6 is linked to Stroke.