MTHFR and ischemic stroke: In ischemic stroke patients, multiple regression analysis showed that plasma metabolites such as (p)CysGly, pMet, as well as MTHFR A1298C polymorphism, were associated with fibrin Absmax, while urinary metabolites such as (u)HTL, uCysGly, and pCysGly were significantly associated with fibrin CLT.