Comparative analysis of CBS deficiency vs. ischemic stroke proteomes suggests that some changes in the CBS deficiency proteome (i.e., those involving the 18 CBS deficiency-specific proteins; Table 3) were related to elevated Hcy and anti-N-Hcy-protein autoantibody levels, whereas other changes were not (i.e., those involving the 22 proteins also affected in ischemic stroke patients). Here, CBS is linked to ischemic stroke.