Our results also revealed that high HMMR mRNA and protein expression is associated with an adverse prognosis in B-ALL pediatric patients (Figure 3B and Figure 6B), which is in agreement with the findings of Tarullo, Beck, and Tzankov in breast cancer, lymphoma, and acute myeloid leukemia, respectively [66,67,68]. This evidence concerns the gene HMMR and breast carcinoma.