ABCC8 and familial hyperinsulinism: Heterozygous, homozygous, and compound heterozygous mutations in the ABCC8 gene have been implicated in familial hyperinsulinemic hypoglycemia (OMIM:256450) and permanent neonatal diabetes mellitus 3 (OMIM:618857), which may present with or without neurological features, and are associated with both autosomal-dominant and autosomal-recessive inheritance patterns.