To prove our findings with a clinically relevant example, based on scientific articles with a main focus on cases characterized by resistance to anti-EGFR, antiangiogenic, 5-fluorouracil (5-FU), chemo and cetuximab therapies [23,24,25,26,27], we constructed a list of genes that are mutated in patients with therapy-resistant colorectal cancer and provided the corresponding mutational attributes. Here, EGFR is linked to colorectal cancer.