The precise mechanisms of crosstalk between ADAM17 and Klotho in the context of podocyte function under hyperglycemic conditions are still not fully understood, but our findings have implications for understanding the interplay between ADAM17 and Klotho in podocytes under hyperglycemic conditions and provide insights into the pathophysiology of kidney-related disorders, particularly those associated with diabetes and its renal complications. This evidence concerns the gene KL and diabetes mellitus.