In comparison with the group D2, TPY3m, when administered for three days, increased the Tg, Tpo, and Dio3 gene expression in the TG, with the Dio3 expression increasing by an average of four times, and normalized the expression of the TSH receptor gene, which tended to increase in T2DM rats (Table 5). This evidence concerns the gene DIO3 and type 2 diabetes mellitus.