Soluble PD-1 and PD-L1 revealed sPD-L1 association with clinically significant PCa (sPDL1 p = 0.031) (Figure S1b), and grade 3 PCa (grade 2 vs. grade 3 sPDL1 = 0.026) (Figure S2b), while sPD-1 showed no differences in any of the clinical features examined. This evidence concerns the gene SPDL1 and posterior cortical atrophy.