Circulating plasma molecules such as soluble PD-L1 and PD-1 (sPD-L1 and sPD-1) have drawn notable focus in recent research due to their potential as prognostic and predictive markers in different cancer types [7,8,9] and demonstrated prognostic significance in our previous research on prostate cancer [10]. This evidence concerns the gene HOXD13 and Familial prostate cancer.