Jing Zhao et al. [48] experimentally induced acute liver injury by intravenous injection of ConA in wild-type (WT) mice and Toll-like receptor-7 (TLR7)-knockout mice and reported that liver injury was diminished in TLR7-deficient mice, demonstrating that TLR7 modulates the expression of TNF-α in intrahepatic Mφs, exacerbating ConA-induced HF. This evidence concerns the gene TLR7 and hydrops fetalis.