Xin Qi et al. [59] reported that abundant microRNA-1 (miR-1) produced in Mφ-derived extracellular vesicles (EVs) stimulated by S. mansoni soluble egg antigen (SmSEA) could stimulate the autocrine growth of TGF-β3 in HSCs by targeting the inhibition of suppressor of cytokine signaling 3 (SOCS3) expression, thus promoting the activation of HSCs and demonstrating that EVs play an essential role in HSCs activation during the progression of schistosomiasis-associated liver fibrosis (SSLF). The gene discussed is SOCS3; the disease is schistosomiasis.