A more detailed analysis of the T-cell compartment revealed a statistically significant decrease in TCRαβ+CD8+ T-cell counts (0.58-fold decrease) at day +4 following the first dose of the vaccine among previously infected non-MBL HD, while SARS-CoV-2 naïve subjects only showed at this time a significant decrease (vs. pre-vaccination) of TCRγδ T-cell counts (0.29-fold decrease) (Figure 2). The gene discussed is CD8A; the disease is Huntington disease.