CD8A and Huntington disease: In contrast, a similar decrease was found for all major T-cell populations in SARS-CoV-2 naïve non-MBL HD after the administration of the second dose of the vaccine, while TCRαβ+CD8+ T-cells were the only T-cell population that showed statistically significant decreased counts (0.42-fold decrease at day +4 vs. 0.04-fold increase at day 0) in previously infected non-MBL HD (Figure 2).