As uPA and the uPA–uPAR system were shown to be involved in tumor aggressiveness, migration, metastasis and invasion in different types of tumors, such as breast, lung and ovarian, both in vitro and in vivo [19,20,21,28,29,30,31,32,33,34,35,36], we analyzed the migration of A1235 and HEK 293 cells. The gene discussed is PLAU; the disease is neoplasm.