Additionally, microglia in the GBM TME experience significant oxidative stress that triggers the activations of nuclear receptor subfamily 4 group A member 2 (NR4A2) and squalene monooxygenase (SQLE), disrupting cholesterol metabolism [163], impairing antigen presentation, and contributing to an immunosuppressive, tumor-promoting environment [164,165]. Here, NR4A2 is linked to neoplasm.