On the other hand, the autophagy pathway, known to provide therapeutic resistance for GBM cells, is initiated by a series of active proteins including autophagy-related (ATG) proteins, ultraviolet radiation resistance-associated gene (UVRAG), beclin 1, phosphoinositide 3-kinase catalytic subunit type 3 (PIK3C3), microtubule-associated protein 1A/1B-light chain 3 (LC3), and p62 [51]. This evidence concerns the gene MAP1LC3A and glioblastoma.