AKT1 and glioblastoma: Glucose uptake by GBM cells is enhanced by the upregulation of glucose transporters (GLUT1) on the plasma membrane, potentially through hyperactivation of the phosphoinositide 3-kinase (PI3K)-protein kinase B (AKT) pathway [15], as well as through the augmentation of hexokinase (HK), HIF1α, and HIF2α [16].