Thus, this study investigated the association of FAS rs1800682 (A/G), FAS rs223476 (G/A), FASL rs763110 (C/T), and FASL rs5030772 (A/G) polymorphisms with the severity of COVID-19 and the development of long COVID, with the aim of identifying whether genetic factors in apoptosis molecules could contribute to the differences in clinical manifestations observed among people infected with SARS-CoV-2, enabling a better understanding of the pathogenesis of the disease. This evidence concerns the gene FAS and COVID-19.