HIF1A and familial pancreatic carcinoma: Gene expression of HIF1α [35], which promotes the development of drug resistance in pancreatic cancer cell lines, and cytosolic NADPH dehydrogenase 1 (malic enzyme 1, ME1) [50,51], which promotes glutaminolysis and is related to stemness in oral cancer cells, were increased in HT29R and CT26R cells, whereas only HIF1α showed increased expression in CT26R cells (Figure 5D).