To analyze the connection between MPP5 and the Hippo signaling pathway in liver cancer patient samples, tissue-micro arrays (TMAs) containing human HCCs and healthy liver tissues were stained for MPP5, YAP, TAZ, the YAP/TAZ target gene mini-chromosome maintenance protein 2 (MCM2), and the proliferation marker Ki-67 [26]. The gene discussed is MKI67; the disease is liver cancer.