In this case, they found an optimal nine-protein model of specific proteins with multi-system expression and correlated with hemoglobin, coagulation factors, hypertension, and high-flow nasal cannula intervention, i.e., (Platelet factor 4 variant (PF4V1), Nucleobindin 1 (NUCB1), CRK Like Proto-Oncogene, Adaptor Protein (CrkL), SerpinD1, Flap Structure-Specific Endonuclease 1 (Fen1), GATA-4, Proprotein convertase subtilisin/kexin type 1 inhibitor (ProSAAS), Parkinsonism associated deglycase (PARK7), and neuroepithelial cell transforming 1 (NET1)). This evidence concerns the gene NUCB1 and hypertensive disorder.