ABCA1 and Niemann-Pick disease: The reasons for this variability can be linked to polymorphisms in genes [5] involved with vitamin E bioavailability like Niemann–Pick Disease, Type C1 (NPC1), Cluster determinant 36 (CD36), Scavenger Receptor Class B Member 1 (SCARB1), and ATP Binding Cassette Subfamily A Member 1 (ABCA1), or vitamin E transport like Apolipoprotein B (APOB), Apolipoprotein A5 (APOA5), and Apolipoprotein E (APOE).