INS and type 2 diabetes mellitus: In contrast, the upregulated miRNAs in our T2D cohort, such as hsa-miR-150-3p, hsa-miR-125a-3p, hsa-miR-223-5p, hsa-miR-143-3p, hsa-miR-29a-3p and hsa-miR-24-3p, are known to be involved in insulin secretion/signaling, glucose homeostasis, insulin resistance, β-cell dysfunction and lipid metabolism [24,34,61,62,63,64,65].