Some of the downregulated miRNAs identified in this study, such as hsa-miR-615-3p, hsa-miR-335-3p, hsa-miR-130b-5p, hsa-miR-17-3p, hsa-miR-937, hsa-miR-1307-3p, hsa-miR-328-3p, hsa-mir-139-3p, hsa-miR-548ag and hsa-miR-548p have been previously linked to T2D mechanisms, including glucose metabolism, insulin signaling and insulin resistance [50]. This evidence concerns the gene INS and type 2 diabetes mellitus.