Since 2020, significant progress has been made in the research of anti-SARS-CoV-2 compounds, with different viral proteins emerging as critical targets for combating COVID-19 [1,8,9,10,11,12,13,14], such as the Spike protein, focusing on its interaction with angiotensin-converting enzyme 2 (ACE2) receptors in host cells and chymotrypsin-like cysteine protease(3CLpro) and papain-like protease (PLpro), which are primarily responsible for proteolytic cleavage of polyproteins pp1a and pp1ab during the replication process [7,15,16]. Here, ACE2 is linked to COVID-19.