NANOG and breast cancer: According to Liao et al. (2023), ursolic acid showed inhibitory effects upon the stemness of MDA-MDB-231 and MCF-7 breast cancer cells by means of (i) the down-regulation of Nanog and Oct4 genes, (ii) decreased EMT, (iii) the reduction of oncogenic micro RNA (miR-9 and miR-221), (iv) the inactivation of FAK/PI3K/Akt/mTOR signaling pathways, and (v) the decreased activity of argonaute-2 (AGO2), a key regulator of microRNA biogenesis [233].