Additional mechanisms of action of the phenolic and non-phenolic diet in CRC, breast, and prostate CSC presented in Chapter 4 include reductions in surface markers, such as CD44 [124,138,218] and CD133 [16,138,144], reduction in transcription factors associated with stemness features, such as Sox2 [145,214,222], Nanog [214,215,226], and Oct3/4 [231,233,246], and chemoresistance markers, such as ALDH [245,249,250]. This evidence concerns the gene SOX2 and colorectal carcinoma.