AKT1 and cancer: In addition, resveratrol inhibits the migration and metastasis of the MDA-MDB-231 cancer cell line by reversing TGF-β1 epithelial to mesenchymal transition, inhibiting the PI3K/AKT signaling pathway, down-regulating MMP-2/MMP-9 enzymes, and down-regulating transcription factors involved in EMT (Snail 1, Slug, Smad3, P-Smad2, P-Smad) [180].