MYC and colorectal cancer: In addition, EGCG enhances 5-fluorouracil (5-FU) chemosensitivity in colorectal cancer stem cells through (i) the down-regulation of the Notch pathway, (ii) the dysregulation of polycomb proteins (Bmi-1, Ezh2, Suz12), (iii) the decreased expression of proto-oncogene gene, c-Myc, and (iv) the up-regulated expression of tumor suppressive microRNAs (miR-34a, miR-145, and miR-200c) [15].