CD44 and breast cancer: Research regarding their anticancer effect on MDA-MDB-231 and MDA-MDB-361 breast cancer cell lines and preclinical studies revealed a significant reduction in colony formation and mammosphere number, along with the down-regulation of several proteins (CD44, cyclin D1, c-Myc, NF-κB) and signal pathways (mTOR-PI3K/AKT) [120].