POU5F1 and breast cancer: In addition, a standardized extract from Piperum longum L. with 25.04% piperine, 2.91% pipernanoline, and 0.61% guinesine showed promising results on CD44+/CD24− breast cancer stem cells through decreased mammosphere formation and the down-regulation of stemness markers (Nanog, Oct4, Sox2, and EpCAM) [246].