STAT3 and cancer: This is another flavonoidic compound that might be a future candidate for the inhibition of different cancer stem cells due to (i) the regulation of matrix metalloproteinases (MMP-2 and MMP-14), (ii) the inhibition of the STAT3 signaling pathway, (iii) the inhibition of epithelial to mesenchymal transition, (iv) the regulation of VEGF activity, and (v) the regulation of immune and inflammatory factors (NF-κB, COX-2, TNF-α, IL-6) [134].