LRP6 and triple-negative breast carcinoma: This compound extracted from olive oil was shown to inhibit CD44+/CD24− stem cells derived from triple negative breast cancer cells (SUM159PT, BT549, MDA-MB-231, and Hs578T) by (i) suppressing Wnt/β-catenin signaling pathways, (ii) decreasing p-LRP6, LRP6, β-catenin, and cyclin D1 protein expression, (iii) down-regulating EMT markers (SLUG, ZEB1, SNAIL, and vimentin), and (iv) down-regulating TGF-β [192].