In a pilot phase I clinical study, with patients diagnosed with colorectal cancer, treatment with a red grape dry extract (GP) (containing resveratrol, 4 μM/kg of dry powder; flavonols, 118 μM/kg; anthocyanins, 700 mg/kg; flavans, 3.9 mg/g—as catechin) at 80 g/day and 120 g/day for 14 days showed promising results, through the decreased expression of colorectal stem cells markers (CD133, LGR5) and the down-regulation of the Wnt signaling pathway. This evidence concerns the gene PROM1 and colorectal cancer.