AKT1 and breast carcinoma: Favorable results on breast cancer stem cells (in vitro and animal studies) were also observed for a blueberry-enriched polyphenolic preparation (by fermentation with Serratia vacci), through the down-regulation of IL-6/PI3K/Akt and ERK1/2, the inhibition of mammospheres formation, and the inhibition of lung metastasis [162].