According to recent research, β-carotene decreased the number of colonospheres in CD133+/CD44+ colorectal cancer cells through (i) the up-regulation of histone H3/4 acetylation, (ii) the down-regulation of DNA methylation, and (iii) decreased oncogenic miRNA-1260b and miRNA-296-3p [221]. This evidence concerns the gene CD44 and colorectal cancer.