HIF1A and Familial prostate cancer: Several published papers have demonstrated the positive relationship between lignans intake and decreased incidence of breast, colorectal, and prostate cancer [182,183,184] through (i) the down-regulation of NF-κB/ HIF1-α signaling pathways, (ii) the decreased activity of the PI3/AKT signaling pathway, (iii) the inhibition of VEGF activity, and (iv) increased apoptosis through Bcl-2 down-regulation.