According to recent research, short-chain fatty acids (mainly butyrate) might influence colorectal cancer stem cells through the down-regulation of Wnt and PI3K/AKT/mTOR signaling pathways and the up-regulation of secreted Frizzled-related protein expression in the Hedgehog signaling pathway (a natural inhibitor of Wnt), the up-regulation of p21 expression, or the inhibition of Notch signaling [242]. Here, AKT1 is linked to colorectal cancer.