POU5F1 and breast cancer: This acid showed promising results on breast cancer stem cells (in vitro and in vivo) by (i) decreasing mammosphere formation, (ii) down-regulating ALDH1, (iii) down-regulating stemness markers (Sox2, Oct4, c-Myc), (iv) up-regulating ferroptosis, (v) increased levels of lipid peroxidation and ROS accumulation, and (vi) the decreased expression of Nrf2 [231].