AKT1 and colorectal cancer: According to recent research, SCFA such as propionate, acetate, and butyrate block Notch signaling, down-regulate PI3K/AKT/m-TOR, Hedgehog, Hippo, and NF-κB signaling pathways and block HIF-1α stimulation, which are essential molecular mechanisms involved in colorectal cancer stem cell proliferation.