Another flavonoid compound found in Citrus fruits, narigenin, might be a future candidate for the inhibition of colorectal cancer stem cells, since it down-regulates several signaling pathways (TGF-β, Notch, MAPK-ERK, PI3kinase/Akt/mTOR, JAK-STAT) and Nrf2 production [139]. The gene discussed is AKT1; the disease is colorectal cancer.