On the other hand, oleic acid showed opposite effects on different cancer cell lines, as follows: oleic acid inhibited the growth of MCF-7, SUM225, HCC1354, and MDA-MDB-231 but significantly increased the proliferation of MCF10DCIS (a ductal carcinoma in situ cell line), through lipid loading and the up-regulation of lipogenic genes (SREBP-1, FAS, ACC1). The gene discussed is FAS; the disease is cancer.