HIF1A and breast cancer: According to Yang K et al. (2020), curcumin combined with glucose nanogold particles (Glu-GNPs) reduced breast cancer stem cell resistance to radiotherapy/chemotherapy through the reduced expression of HIF-1α and HSP90 (heat shock protein) and the down-regulation of ABCB1/ABCG2 efflux transporters [210,211].