Moreover, diallyl trisulfide (DATS) suppresses the activity of breast cancer stem cells by the down-regulation of stemness markers (Nanog, Oct4, ALDH1, CD44), increased apoptosis (up-regulation of Bax protein, caspase-8, caspase-9, caspase-3), and the inhibition of Wnt/β-catenin signaling pathways [250]. Here, POU5F1 is linked to breast cancer.