CD4 and primary biliary cholangitis: Differential expression analysis of data extracted from publicly available GEO datasets GSE119600 [35] and GSE93170 [36] showed that the expression of HVEM was elevated in PBC patients compared to HCs in both whole-blood transcriptome (GSE119600, MWp = 7.1 × 10−6; HC/PBC n = 47/90) and (to a lesser extent) in CD4+ T cells (GSE93170, MWp = 0.065; HC/PBC n = 6/6) (Figure 6).