Finally, observations in Waldenström’s macroglobulinemia suggest that monoclonal IgM, the principal diagnostic element of SchS, may identify autoantigens on myeloid cells, thereby initiating NLRP3 inflammasome activation linked to the production of proinflammatory cytokines, particularly interleukin-1β [137]. Here, CD40LG is linked to Waldenstrom macroglobulinemia.