The overall impact of these effects on immune responses can be paradoxical, i.e., although p110δ inactivation in mice causes deficient T cell effector responses, the stronger functional impairment of Tregs caused by p110δ inactivation leads to protection against different types of cancer, and this effect can be mimicked by the administration of p110δ-specific inhibitors [21,52]. The gene discussed is PIK3CD; the disease is cancer.