When oxidative stress results from an imbalance between ROS production and the antioxidant defense system, it induces inflammatory mediators such as interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), and interleukin-6 (IL-6) to be highly upregulated in osteoarthritis joints, inducing ROS production and the expression of matrix-degrading proteases, leading to chondrocyte apoptosis and joint dysfunction [18]. Here, TNF is linked to osteoarthritis.