In addition, the role of LD proteins, including Plin1, in human macrophages was also recently investigated in human carotid atherosclerotic plaque samples and cultured macrophages derived from peripheral blood monocytes [81], demonstrating that Plin1 expression was associated with plaque stability and the anti-inflammatory phenotype, whereas Plin2 was primarily expressed in arterial plaques in symptomatic stroke patients and was related with the inflammatory potential of macrophages. The gene discussed is PLIN1; the disease is Stroke.