The results showed that pathways such as proteasome, synaptic vesicle cycle, oxidative phosphorylation, PD, Huntington disease, prion disease, and spinocerebellar ataxia were significantly positively correlated with AGPAT2, ASAH2, and MECR, and significantly negatively correlated with FA2H, suggesting that these four genes may play essential roles in protein degradation, neural signal transmission, energy metabolism, and neurodegenerative diseases. This evidence concerns the gene ASAH2 and prion disease.