INS and Insulin resistance: There are several descriptions of insulin resistance: “a state of reduced responsiveness in insulin-targeting tissues to physiological levels of insulin” [65] or “a state of a cell, tissue or organism in which a greater than normal amount of insulin is required to elicit a quantitatively normal response” [66], or “an inability of some types of tissues to respond to normal insulin levels, and thus, higher than normal levels of insulin are required to maintain the normal function of insulin” [65].