EDN1 and obesity due to melanocortin 4 receptor deficiency: Statistical significance for the rest of the biomarkers, namely ET-1, aVCAM-1 ADAMTS-1 and IL-6, was not achieved in our study, which might be due to several factors, like the stable nature of CAD in the studied population, similar prevalence of risk factors like diabetes, obesity and hypertension in both groups, higher prevalence of smoking in the non-CAD group, the presence of intimal thickening of the coronary arteries in some patients from non-CAD group, and finally a relatively low advancement of atherosclerosis in CAD group.