A study correlating methylation and gene expression identified several hub proteins associated with pituitary adenomas, including DCC, DLG5, ETS2, FOXO1, HBP1, HMGA2, PCGF3, PSME4, RBPMS, RREB1, SMAD1, SOCS1, SOX2, YAP1, and ZFHX3 [24]. The gene discussed is RREB1; the disease is pituitary gland adenoma.