A study correlating methylation and gene expression identified several hub proteins associated with pituitary adenomas, including DCC, DLG5, ETS2, FOXO1, HBP1, HMGA2, PCGF3, PSME4, RBPMS, RREB1, SMAD1, SOCS1, SOX2, YAP1, and ZFHX3 [24]. The gene discussed is SOX2; the disease is pituitary gland adenoma.