A study correlating methylation and gene expression identified several hub proteins associated with pituitary adenomas, including DCC, DLG5, ETS2, FOXO1, HBP1, HMGA2, PCGF3, PSME4, RBPMS, RREB1, SMAD1, SOCS1, SOX2, YAP1, and ZFHX3 [24]. Here, PSME4 is linked to pituitary gland adenoma.