Further analysis of GSE25673 revealed that the levels of CASP1, GSDMD, IL1B (Figure 1C), and NLRP3 (Figure 1D) were significantly higher in individuals with schizophrenia compared to the control group, while the levels of GSDME (Figure 1C) and NLRC4 (Figure 1D) individuals with schizophrenia were lower than those in the control group, These findings suggest that the expression of the pyroptosis-related genes, particularly CASP1, GSDMD, IL1B, and NLRP3, is significantly elevated in neurons derived from iPSCs of schizophrenia patients compared to healthy individuals. The gene discussed is GSDMD; the disease is schizophrenia.