Two categories can be distinguished between CRC cell lines based on the degree of NLG1 expression; one in which NLG1 was very low or absent named “NLG1 null” (such as HCT8, HT-29, and HCT116) and another constituted by the “NLG1 upregulated” (such as NCI-H716, MDST8, SNU-C2A, COLO320DM, HuTu 80, SNU-175, SNU-503) [4]. The gene discussed is NLGN1; the disease is colorectal carcinoma.