For this aim, we first assessed the effect of exosomes of NLG1-expressing CRC cells on the M0 macrophage polarization by analyzing the mRNA expression level of macrophage markers (CD206, CD80) and pro-inflammatory cytokines/chemokines including IL8, IL6, IL1β, and TNFα. The gene discussed is CXCL8; the disease is colorectal carcinoma.