Consistently, as illustrated in Figure 3H,I, Gboxin treatment under low-glucose conditions led to a reduction in the protein expression of GPX4 and Nrf2 and an increase in COX2 expression in the two cervical cancer cell lines, indicating that under low-glucose conditions, Gboxin may induce ferroptosis by regulating the level of Nrf2. The gene discussed is GPX4; the disease is cervical cancer.