Accordingly, the truncation of the C-terminus of CPSF6 (e.g., a truncation at residue 358, CPSF6-358) leads to the localization of the protein to the cytoplasm and inhibits HIV-1 infection by binding to the capsid and sequestering it from the nucleus [196,200,202,203]. The gene discussed is CPSF6; the disease is HIV-1 infection.