Recently, biased GPR84 agonists [22] like 6-OAU [25] and ZQ-16 [26] were developed, showing potent activation of GPR84 and promoting pro-inflammatory responses in macrophages [11,13,25,27,28,29], such as cytokine production, migration, and phagocytosis of cancer cells. This evidence concerns the gene GPR84 and cancer.