Increased levels of heparanase were demonstrated in numerous hypercoagulable clinical set-ups, including women using oral contraceptives [23], women at delivery [24], patients following orthopedic surgery [25], patients with diabetic foot [26], and patients with lung cancer [27], retinal vein thrombosis [28], and prosthetic heart valve thrombosis [29]. The gene discussed is HPSE; the disease is lung carcinoma.