Analyzing the frequency of co-occurrence of genotypes of VDR gene polymorphisms in groups distinguished based on T-score values, it was observed that the co-occurrence of genotypes GG (rs1544410) with GG (rs11568820) statistically significantly increases the risk of osteopenia 35.7% vs. 23.1% in the control group; OR = 1.85 95%CI: 1.051–3.244; p = 0.032. Here, VDR is linked to Osteopenia.