Compared to CAR T-cells, non-transduced T-cells from SLE and IIM patients and HDs showed a higher proportion of CD8+ CD45RO− CCR7+ CD95+ stem cell memory T-cells (Tscm) (HD CD8+ UNTR: 24.4 ± 2.7% vs. HD CD8+ CAR: 10.1 ± 3.1%; SLE CD8+ UNTR: 20.7 ± 5.1% vs. SLE CD8+ CAR: 4.5 ± 0.6%; IIM CD8+ UNTR: 26.1 ± 1.8% vs. IIM CD8+ CAR: 11.0 ± 2.9%) (Figure 2F). The gene discussed is FAS; the disease is systemic lupus erythematosus.