The blood glucose-lowering action of GLP-1 is a glucose-dependent function: GLP-1 reduces blood glucose levels only when hyperglycaemia is present, such as after a meal, while as the postprandial blood glucose levels fall in response to GLP-1, the action of GLP-1 is self-terminating without leading to hypoglycaemia [57]. Here, GLP1R is linked to Hyperglycemia.