CD4 and cutaneous melanoma: Importantly, in skin melanoma (SKCM), OPTN expression was positively correlated with infiltration of Th1, Th2, central memory infiltrates, cytotoxic, CD4/CD8 T cells, NK cells, effector memory T cells, exhausted T cells, B cells, γδ T cells, Tfh and iTreg cells, while it was negatively correlated with infiltration of CD-naïve, neutrophils, NKT cells and monocytes (Figure 4b).