OPTN and glioblastoma: For example, OPTN mRNA levels were significantly anti-correlated with its methylation levels in GBM (cg17405055, Spearman’s rho = −0.62, FDR = 2.14 × 10−6), UCEC (cg17405055, Spearman’s rho = −0.52, FDR < 0.0001), LAML (cg24176744, Spearman’s rho = −0.50, FDR < 0.0001), UVM (cg16907766, Spearman’s rho = −0.48, FDR = 7.01 × 10−6) and other tumors (Supplementary Table S5).