Given the above, the purpose of this investigation was to examine the occurrence and potential relationship between candidate gene variants such as KCNJ1 (rs675388, rs59172778, rs12795437, and rs11600347), WNK1 (rs880054), NPPA (rs5065), STK39 (rs6749447), LUC7L2 (rs6947309), NEDD4L (rs75982813, rs292449), NPHS1 (rs3814995), BDKRB2 (rs1799722, rs8012552), and CACNA1C (rs2239128, rs2238032, rs1051375) and hypertension in the Jordanian Arab population. The gene discussed is NEDD4L; the disease is Hypertension.