CACNA1C and diabetes mellitus: CACNA1C rs2238032 was found to have a significant relationship with creatinine clearance (p-value = 0.022), other medicines for chest pain (angina) (p-value = 0.0001), B-blocker and thiazide diuretics (p-value = 0.003), number of HTN drugs from all classes (p-value = 0.006), and diabetes treatment (p-value = 0.0001).