rs12795437 and rs11600347 of KCNJ1 were significantly associated with chronic kidney disease (p-value = 0.0002), smoking (p-value = 0.03 and 0.014), HDL levels (p-value = 0.04), thiazide diuretics (p-value = 0.004), calcium channel blocker (CCB) (p-value = 0.005), immune-suppressive/allergies (p-value = 0.002), dialysis (p-value = 0.008), other stomach drugs (p-value = 0.003), white blood cell (WBC) count (p-value = 0.016 and 0.018), and total protein level (p-value = 0.02). This evidence concerns the gene KCNJ1 and chronic kidney disease.