In this study, we examined the associations of sixteen single nucleotide polymorphisms (SNPs) from nine genes (KCNJ1 (rs675388, rs59172778, rs12795437, and rs11600347), CACNA1C (rs2239128, rs2238032, and rs1051375), WNK1 (rs880054), NPPA (rs5065), STK39 (rs6749447), LUC7L2 (rs6947309), NEDD4L (rs75982813 and rs292449), NPHS1 (rs3814995), and BDKRB2 (rs1799722 and rs8012552)) with the risk of hypertension in the Jordanian population. This evidence concerns the gene NPPA and Hypertension.