The effects of systemic comorbidities in diseases such as advanced cancer, congestive heart failure and chronic kidney disease significantly affect albumin levels but do not always have a direct correlation with perilesional skin condition, especially when the latter is under intensive care, reinforcing the idea that albumin and epithelialization are influenced by distinct but co-existing pathophysiological processes in this population [49]. This evidence concerns the gene ALB and congestive heart failure.