Conversely, carriers of path_MSH6 [8,79] and path_PMS2 [80] genes have a lower risk of developing CRC, which may be due to their lower penetrance and later age of onset, and can be further reduced by regular colonoscopic surveillance or even become near to zero in carriers of PMS2 [78,81,82]. Here, MSH6 is linked to colorectal carcinoma.