Genetic risk loci for CVD include the low-density lipoprotein cholesterol receptor (LDLR) (Figure 3) or proprotein convertase subtilisin/kexin type 9 (PCSK9), as they result in hypercholesterolemia, which is a traditional risk factor for CVD [117,118]. The gene discussed is PCSK9; the disease is familial hypercholesterolemia.