INS and type 2 diabetes mellitus: The brown adipose tissue plays an important role in the regulation of energy and sugar homeostasis and is associated with levels of glucose and insulin resistance in peripheral tissues [49], whereas the white adipose tissue (visceral adipose tissues surrounding the abdominal region) is the main source of the inflammatory markers in T2D, as it secretes the cytokines (tumor necrosis factor-alpha and interleukins 1, 6, 10), adipokines, chemokines, plasminogen activator inhibitor-1, and immune cells such monocyte chemoattractant protein [49,50].