CARD14 GOF variants, particularly the PSORS2 single-nucleotide polymorphism (SNP), are major genetic risk factors for psoriasis, leading to enhanced NF-kB activation, the upregulation of psoriasis-associated genes in keratinocytes, and triggering acute inflammatory responses and recruitment of inflammatory infiltrate, making CARD14 a key regulator of skin inflammation [25]. Here, NFKB1 is linked to psoriasis.